Yes, just be sure to use the right earbud. That’s because when you pair your QuietComfort® Earbuds to your phone, tablet, or laptop, the Bluetooth connection occurs between the source device and the right earbud. The signal is then beamed over to the left earbud. So, if you were to take out the right earbud and place it on a table, that earbud would go to sleep in about 20 minutes and, when that happens, the left earbud would lose its Bluetooth connection. Similarly, if you were to place the right earbud in the charging case and close the lid, the left earbud would lose its connection immediately.
As for calls, it’s worth noting that the microphone system that picks up your voice is located in the right earbud — another good reason to opt for the right earbud when you feel like only wearing one.
Just be aware, when you choose to listen to the right earbud only, you won’t be able to access the touch controls on your left earbud, so you will need to adjust the noise cancelling through the Bose Music app and manage your content directly on your device.